Fears and thoughts as we move to level ONE

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3 months 1 week ago - 3 months 1 week ago #813336 by TNaicker
Perchance, I just heard CR7's "smell the coffee" comment...have to call out his smug arrogance...he and the other Thiefs in Chief and public sector employees can "smell the coffee" as they have not lost their livelihoods in the last year of lockdowns...dumbtist id10ts the lot of them...

And the public sector unions are demanding CPI + 4% for next collective bargaining agreement...with the private sector that generates economic growth having shed about 3 million jobs (and the taxes that go with that), expect more money printing by the SARB to provide liquidity to fund this insanity...and the inflation to follow in the years to come will hurt everyone (the poorest most) and see a return to mid-teen interest rates of 10-15 years ago...

Dumbtist id10ts...

Life's too short to have a long face...so, cherish the good, learn from the bad and forget the rest...
Last edit: 3 months 1 week ago by TNaicker.

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3 months 1 week ago - 3 months 1 week ago #813388 by mikesack
IVERMECTIN TO FURTHER LOWER SA COVID NUMBERS...…………….PROFESSORS RECOMMEND USE WITHOUT WAITING FOR VACCINES...…..

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3 months 1 week ago - 3 months 1 week ago #813390 by mikesack

mikesack wrote: IVERMECTIN TO FURTHER LOWER SA COVID NUMBERS...…………….PROFESSORS RECOMMEND USE WITHOUT WAITING FOR VACCINES...…..

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PROFESSOR ELI SCHWARTZ...…………………...

SA
WWW.BIZNEWS.COM SATURDAY 27 FEBRUARY 2021 BIZNEWSCO


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That can be a great advantage, because then it can break the transmission chain and it also may shorten the isolation period. To find a drug that within maybe a few days of treatment, you can be free of the virus is very valuable. The bottom line is that actually it's really acting well. It's shortened the viral shedding period. Therefore, if we are going to adopt it, people can be isolated for a shorter time. And therefore, we think that it really can help to break the transmission chain.”

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On their plan for the use of Ivermectin:
“Our plan is to go to people at high-risk. That means people older than 50, with some risk factors like obesity, hypertension and diabetes, and to give to the drugs specifically to this group of the population, to see whether we can prevent hospitalisation. To give it at the early stage of the disease - when they're still at home - to see whether the admission rate will diminish, if you compare it to the placebo.”
On Ivermectin as a prophylaxis:
“The other way to use it is as a prophylaxis. When I say prophylaxis, it means if you have somebody who was verified to have the disease and he has a family around him, you give it to the other family members immediately. This will allow [us] to see whether you really can reduce the number of new infections in this case. It can act, in a way, like a vaccine. I think that this is the importance of the disease. I know that around the world (in many places) the drug is given. However, without good evidence for it. I think governments - especially in the West - where they have more budget to use for it, we should continue and conduct properly done studies to show really the effectiveness of the drug.”

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Read the full article here
Ivermectin, a medicine authorized by INVIMA to treat patients with mild, asymptomatic or suspicious Covid-19.
Professor Eli Schwartz on his Ivermectin research:
“We decided to go for Ivermectin, because as part of the tropical institute, we know the drug well. We know the safety profile of the drug and when Covid-19 started and there was some new data showing that in vitro, it's highly effective against the coronavirus. So, we decided to go for it. Just to remind you, at that time, most of the world was running for the hydroxychloroquine as the saviour of the world. We decided to go for something else.
My decision was to go for the early stage of the disease, to see whether it's can act a bit like a vaccine. That means if you give it at the early stage - it doesn't matter if the patient is mild, ill or even asymptomatic - maybe you can shorten the, let's call it the viremic phase, the phase of which the virus is shedding and contaminating the environment.

FIND OUT HOW
There are some people who, even if a vaccine is available, they cannot get it. So you'll have a subpopulation who continue to shed the virus and infect each other. For example, to use this drug in schools, whenever you have one case in a classroom and you give it and prevent the spread of the disease is highly important. Not to forget - especially if we are talking to South Africa - with the variant - there are suspicions that the vaccine will not cover it properly. This is the situation now. Nobody knows what's going to happen in the future. Do we have new mutations with more variability? Perhaps the vaccine will be less effective? I think to have an antiviral agent is highly important in so severe a disease. We hope we will not need it in the future. But for now, I think we urgently need and to continue to work on Ivermectin.
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3 months 1 week ago #813739 by mikesack
Pro Vaxxers need to roll up their sleeves ……………….and cross their fingers and curl the toes.:whistle:



www.businessinsider.co.za/south-africa-v...tudy-mutation-2021-3



Study finds Pfizer and Moderna’s shots 10 times less effective against SA’s dominant variant



Dr. Catherine Schuster-Bruce , Business Insider US

Mar 08, 2021, 09:13 PM



















Moderna
Boxes containing Moderna Covid-19 vaccine. (Via Getty)


Pfizer-BioNTech and Moderna's Covid-19 shots were at least 10 times less effective against the coronavirus variant first found in South Africa, in a new study.
A small lab study – using real versions of the coronavirus – found much lower levels of protective antibodies in both cases.
A mutation on the variant called E484K appeared to be a "major contributor," the study authors said.
Visit Business Insider SA for more stories.

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Covid-19 vaccines from Moderna and Pfizer-BioNTech appear significantly less effective against the coronavirus variant first found in South Africa, a lab study has suggested.

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The percentage of protective antibodies that neutralised the variant, called B.1.35, was 12.4 times lower for Moderna's Covid-19 shot than against the original coronavirus, and 10.3 times lower for Pfizer's, the study authors said.







This was a bigger drop than in previous lab studies testing the vaccines against manufactured forms of the variant, they said. For this study, the researchers used real forms of the variant taken from people who had caught the virus.


B.1.351 was first detected in South Africa in October 2020. It has since spread to at least 42 countries. Data suggests it is the dominant variant in South Africa.







The researchers found that the antibody activity from both vaccines was "essentially unchanged" against the variant first found in the UK, B.1.1.7.

The scientists, from Columbia University, also tested lab-made viruses that had certain mutations. They said that one specific mutation, E484K, appeared to be a "major contributor" to the B.1.351 variant's ability to evade the antibody response. E484K is not usually present in B.1.1.7, the variant first found in the UK.

The study has been accepted by science journal Nature but not yet published.

Taking samples from the real world

In the experiment, scientists took 10 blood samples from people who had received two doses of Pfizer's vaccine, 28 days after their second dose, and 12 samples from those who had received two doses of Moderna's vaccine, 43 days after their second dose. They then compared how well antibodies in the blood samples "neutralised" the original coronavirus, compared to real-life B.1.1.7 and B.1.351 coronavirus variants.

The sample size was small, and the antibody response is just one aspect of the immune response, so it remains unclear how well the vaccines work against the variant first found in South Africa in real-life.

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Pfizer has conducted petri-dish tests before that showed a less potent antibody response against a lab-made coronavirus variant that mimicked the variant first found in South Africa. It was not the exact B.1.351 variant.

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Moderna ran similar tests, and said that its vaccine held up well against the mutations found in B.1.1.7, the variant first found in the UK, but less well against the mutations found in B.1.351, the variant first identified in South Africa. Again, it used lab-made variants.

Both companies said in January they were developing booster shots specifically to tackle the B.1.351 variant.

Neither of the vaccines has been properly tested against the variant first found in South Africa in the real-world.

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In Israel, Pfizer's vaccine has been shown to be highly effective against the B.1.1.7 variant, first found in the UK. About 80% of Israelis with Covid-19 are infected with B.1.1.7.


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The Covid-19 vaccine from Johnson & Johnson was less effective in the clinical trials that took place in South Africa.

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3 months 1 week ago #813743 by Dave Scott
ANC top 6 to give Zuma more space.

We can only hope this means a bigger cell ?

Talk is that Jooste should get to Germany to avoid SA jail.

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3 months 5 days ago #813920 by Mac
On this day last year, COVID-19 was declared a pandemic by the head of the World Health Organization


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3 months 5 days ago #813923 by Dave Scott
Load shedding back for a couple of days 😎

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3 months 5 days ago #813924 by mikesack

Mac wrote: On this day last year, COVID-19 was declared a pandemic by the head of the World Health Organization


Yeah. The fokkers Who declared the Swine Flu outbreak a pandemic in 2009.
As a result of the speedily processed vaccines and the side effects, with the pandemic fizzling out, many countries had to destroy their stockpiles of the vaccines.

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3 months 5 days ago #813926 by TNaicker

Dave Scott wrote: Load shedding back for a couple of days 😎


May extend into the weekend...:(

Life's too short to have a long face...so, cherish the good, learn from the bad and forget the rest...

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3 months 4 days ago - 3 months 3 days ago #814021 by mikesack
Sad news of the passing of HRH King Goodwill Zwelithini due to Diabetes complications.
May his dear soul RIP.:(
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3 months 3 days ago #814093 by Dave Scott
Early start with load shedding
6.00 to 8.30 😎

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3 months 1 day ago - 3 months 1 day ago #814279 by Dave Scott
Some much happening and all going the wrong way.........

Time for a song, one of Daves favs

Last edit: 3 months 1 day ago by Dave Scott.

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3 months 1 day ago #814291 by TNaicker
Great song...

Let It Be is also a great one...

Life's too short to have a long face...so, cherish the good, learn from the bad and forget the rest...

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3 months 1 day ago #814292 by Mossel
Or we on the road to no where. Talking heads

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3 months 15 hours ago - 3 months 15 hours ago #814360 by Dave Scott
Power just came back on, we lost around 5 hrs today.
Hope they know it Cheltenham week?

Should the police shoot a couple of student's? Or should they just let them carry on and burn the university's, so when they have FREE education, they can learn from home 😢

For fear of sensitive viewers just a rubber bullet on the bum 😷
Last edit: 3 months 15 hours ago by Dave Scott.

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3 months 8 hours ago #814365 by fingers
Don't you have an UPS Dave?
Can't live without it with all this load-shedding

Ignorance doesn't kill you, but it makes you sweat a lot.
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2 months 4 weeks ago #814589 by mikesack

mikesack wrote: IVERMECTIN TO FURTHER LOWER SA COVID NUMBERS...…………….PROFESSORS RECOMMEND USE WITHOUT WAITING FOR VACCINES...…..

www.biznews.com/wp-content/uploads/2021/02/BN_Digest_270221.pdf




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South African Report: Ivermectin to be Accepted by SAHPRA for Widespread Societal Use During the COVID-19 Pandemic but That Won’t Matter Much
South African Report Ivermectin to be Accepted by SAHPRA for Widespread Societal Use During the COVID-19 Pandemic but That Won’t Matter Much
TrialSite Staff By TrialSite Staff March 16, 2021
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Ivermectin SAHPRA South Africa



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1

In what appears to be a bittersweet victory in South Africa for ivermectin proponents, TrialSite has access to court documents out of that country that on Monday March 15, 2021 the South African Health Products Regulatory Authority (SAHPRA) communicated to a legal challenger that the regulatory body would change its policy to accept the use of ivermectin as a means of targeting SARS-CoV-2, the virus behind COVID-19. Reports are that starting Wednesday March 16, once a particular ivermectin-based product (a cream) is registered, doctors can prescribe ivermectin without having to apply to SAHPRA to do so and compounding pharmacists and licensed doctors can then compound ivermectin for human use. A victory in spirit only for a group that was taking legal action, led by the African Christian Democratic Party (ACDP) and an activist group known as AfriForum as they filed court motions against SAHPRA and the Minister of Health for access to the drug. Yes, in a twist, the ingredients to produce the drug must be accessed within the country. If production relies on imports, then the Section 21 rules apply, meaning each and every treatment requires a consultation with SAHPRA. Hence from Wednesday onward, while there is a legal pathway for prescribing physicians and pharmacists to compound ivermectin for purposes of treating COVID-19, the actual practicalities of compounding and distributing the medication make pragmatic implementation nearly impossible. The decision has essentially created more layers of bureaucracy, which serve to keep cost-effective, generic treatments at bay. Only a regulatory waiver by the Minister of Health could change this situation.

COVID-19 in South Africa




Explore Further





The War on ‘Misinformation’ Claims Two Victims. Truth. And the Right to Treatment.



The War on ‘Misinformation’ Claims Two Victims. Truth. And the Right to Treatment.




Dr. Paul Marik Ivermectin Works and Should be Accepted for Large Observational Studies



Dr. Paul Marik: Ivermectin Works and Should be Accepted for Large Observational Studies

One of the worst hit countries in the African Continent, South Africa, experienced two large waves during the pandemic thus far. The first during July of 2020 where as many as 13,000 cases per day were recorded. A second and more severe spike occurred at the end of 2020 and into January 2021. While cases have again waned the vaccination situation is by no means stable or secure (in that there are a lot of people to vaccinate), and with no approved therapeutic treatments for mild to moderate cases the many positive results from dozens of studies led to interest in ivermectin as a treatment.


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Reports from the country indicate the distribution of SARS-CoV-2 follows race and economic class lines. According to one member of the group known as the Ivermectin Interest Group, about 70% of those individuals with Black heritage produced the coronavirus antibodies; 50% of Asian populations have been exposed while 40% of so-called mixed-race produce coronavirus antibodies. Of the white population, that figure is 20%.


Also, indications are that in poorer areas of major urban areas, such as Soweto, experience such high concentrations of exposure that the topic of herd immunity even is mentioned.

These general demographic trends can be seen in America as well given the social determinants of health represent a global condition.
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Vaccination in South Africa

As TrialSite reported in February, the AstraZeneca vaccine was put on hold as data from a university study revealed that particular product afforded the population minimal protection against mild-to-moderate infection caused by that nation’s predominant SARS-CoV-2 variant.

Now the Johnson and Johnson vaccine has arrived. Thus far, about 150,000 people in this country have been vaccinated between February and March. But with nearly 60 million people, the current pace of inoculation would take years to ensure the entire population was vaccinated. Many health professionals here believe therapeutic options such as ivermectin represent a key tool in a holistic strategy to care for as many people as possible.


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The Fight for Ivermectin as a Treatment

As TrialSite has chronicled, South Africa as it turns out represents a key battleground for the use of the drug to treat people against COVID-19. In February, the AfriForum and the ACDP launched a legal action against SAHPRA and the Minster of Health to secure access to the drug as a treatment for COVID-19. In parallel, as TrialSite reported, SAHPRA first criminalized importation and potentially use but then allowed limited access via a program based on the country’s law known as section 21 of the Medicines and Related Substances Act. TrialSite commended SAHPRA for at least softening its stance, if just a bit.

Bureaucratic Layers

But the dependence on Section 21 causes just as many challenges because each time a doctor wanted to prescribe ivermectin for a COVID-19 case, they were subjected to a cumbersome bureaucratic process taking far too long, especially in pandemic conditions. Although they (SAHPRA) made some exceptions for emergencies, the level of bureaucracy had no place in the context of treating people during a pandemic.

Hence, AfriForum and the ACDP took legal action to change the situation. They believed that this program based on Section 21 failed to support the purpose intended—that is, rather than help doctors it hindered them from treating patients who were ill as a consequence of SARS-CoV-2 infection. Under the new rules, doctors had less resources to treat patients, too much time was passing, and too many patients ill. Before the enactment of Section 21 and the importation rules, doctors actually were entitled to prescribe the drug and credentialled, licensed doctors and pharmacists could compound it without having to submit applications to SAHPRA. But the new SAHPRA program precluded the ability for physicians and pharmacists to compound ivermectin medicine, hence reducing public’s access to the drug during the pandemic.

The Breakthrough

On Monday 15 March 2021, SAHPRA informed the ACDP that an ivermectin product should be registered by Wednesday 16, March 2021. This means that as soon as this product is registered, doctors can prescribe ivermectin without having to apply to SAHPRA to do so and compounding pharmacists and physicians can compound ivermectin for human use.

Deemed a great victory for the people of South Africa who have suffered under the scourge of the pandemic as a therapy that when prescribed under licensed, credentialed physicians numerous studies show it to have an positive impact on the disease, cutting the duration of illness and even in some studies evidencing it can reduce the mortality rate.

Moreover, as the ACDP was concerned about not only the lack of access during the pandemic but also a burgeoning black market where profiteers and criminal gangs would exploit the situation to maximize their profits, the move reported today, although it must be validated, is a big one.

The Reality

SAHPRA maneuvered and used the law that ironically was used against them by their opponents. As ivermectin was in fact registered in the past, they selected a cream-based product that includes ivermectin as an ingredient. Now the rules stipulate that licensed individuals can compound ivermectin based on this particular product registration. But this act doesn’t help any doctor that wants to produce hundreds of thousands of doses to treat at least 1.5 million cases in the country. While South Africans must continue to wait for vaccination, although Johnson and Johnson continues to plan to send more doses, there isn’t much practically that physicians can do from this apparent compromise.


Call to Action: TrialSite will provide updates as they are available. Governments and health authorities around the world have focused on vaccination, and importantly financing with public money pharmaceutical therapeutics, such as monoclonal antibodies used as prophylaxis but the prospect of generic, low cost ivermectin doesn’t look promising. The groups in South Africa taking on the legal battle for a low cost generic at least stood for something important and admirable and should be commended.
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Related




SAHPRA Further Explains its Ivermectin POV, Monitors Ongoing Studies & Embraces Research But Nation Still Criminalizes Import for COVID-19 Use


SAHPRA Further Explains its Ivermectin POV, Monitors Ongoing Studies & Embraces Research But Nation Still Criminalizes Import for COVID-19 Use






South African Breakthrough! SAHPRA Announces Controlled Compassionate Access to Ivermectin

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2 months 4 weeks ago #814599 by Mac
For those who thought that lockdown would leave couples with little else to do than procreate, there was a surprise - not a baby boom but a baby bust. Research shows that the US is facing the biggest slump in births in a century and in parts of Europe the decline is even steeper.

BBC


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2 months 4 weeks ago #814605 by Dave Scott
Good for the planet ?
Over population has been a major problem for years.

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2 months 4 weeks ago #814665 by Mac
Italy, Germany, Hungary, Poland, Czech - into third wave lockdowns.
Now Paris to lockdown in 3rd wave.

We will need to brace ourselves again.


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